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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Annu Rev Fluid Mech. 2018 Jan;50:459–482. doi: 10.1146/annurev-fluid-122316-045259

Figure 3.

Figure 3

A small network of initial lymphatics. Top inset shows endothelial-cell primary valves, consisting of unbonded overlaps between ECs, and anchoring filaments to surrounding fibrous tissue. Lower left inset shows characteristic oak-leaf EC configuration, with discontinuous button junctions. Little is known about where, i.e. how far along the network, such cells give way to ECs with continuous zipper junctions (inset at bottom right). Although not divided into lymphangions, initial lymphatics can also have sparse secondary (intravascular) valves. Based on published material (Baluk et al 2007, Galie & Spilker 2009, Murfee et al 2007, Schmid-Schönbein 1990a).