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. 2018 Apr 27;13(4):e0196397. doi: 10.1371/journal.pone.0196397

Fig 5. IgG binding antibody responses to gp120 A244gD and gp70V1V2 scaffolds in rectal secretions (RS).

Fig 5

Reciprocal titers of IgG binding antibody responses to (A) gp120 A244gD (CRF01_AE), (B) gp70V1V2 92TH023 (CRF01_AE) and (C) gp70V1V2 Case A2 (subtype B) in RS are shown along with numeric depiction of geometric mean titers above panels. Each group is color coded; red, ALVAC-HIV/AIDSVAX®B/E (ALVAC/AIDSVAX); green, AIDSVAX®B/E (AIDSVAX); blue, ALVAC-HIV (ALVAC). Error bars depict 95% confidence intervals. The cut-off level of responses (0.5-fold the reciprocal titers of the initial dilution of specimens) is shown by the dotted line. RV305 vaccine administration time points are indicated by black arrows (weeks 0 and 24). The non-parametric Mann-Whitney U Test was used to assess within-group comparison of IgG responses between time points indicated by black bars. Comparisons reaching statistical significance at the level of p<0.05 are shown. *p<0.05 to 0.001, &p<0.001.