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. 2018 Apr 21;5(1):e000277. doi: 10.1136/bmjresp-2018-000277

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Slope of FEV₁/FVC by Lyso-Gb3 category FEV₁/FVC z-score (y-axis) by age (x-axis) categorised by three categories according to Lyso-Gb3 levels (red, lowest Lyso-Gb3 level of 8.6 ng/mL; green, mid level of Lyso-Gb3; blue, highest Lyso-Gb3 level of 21.3 ng/mL). Patients with highest Lyso-Gb3 levels had faster FEV₁/FVC z-score decline compared with those with lower levels. Median (IQR) spirometric follow-up time was 7.7 (3.7, 10.1) years.