Table 5.
Summary of probability distributions of LDEF, DREF, and DDREF for all solid cancers calculated using stepwise procedures for combining probability distributions of LDEF and DREF from epidemiological studies to obtain preferred DDREF distributiona
| Step in procedure |
Type of combined estimate | Percentile of probability distribution | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| 2.5th | 5th | 50th | 95th | 97.5th | ||
| Step 1 | LDEF for cancer incidence (n = 3)b | 0.89 | 0.96 | 1.4 | 2.2 | 2.4 |
| LDEF for cancer mortality (n = 6) | 0.92 | 0.97 | 1.5 | 5.2 | 7.0 | |
| DREF for cancer incidence (n = 2) | 0.31 | 0.41 | 1.2 | 5.2 | 8.8 | |
| DREF for cancer mortality (n = 3) | 0.26 | 0.31 | 0.72 | 3.1 | 5.4 | |
|
| ||||||
| Step 2 | LDEF for cancer incidence and mortality combined, with relative weights of 2:1 assigned to incidence- and mortality-based distributions | 0.90 | 0.96 | 1.4 | 3.0 | 4.5 |
| DREF for cancer incidence and mortality combined, with relative weights of 2:1 assigned to incidence- and mortality-based distributions | 0.28 | 0.36 | 1.0 | 4.7 | 7.7 | |
|
| ||||||
| Step 3 | DDREF obtained by combining LDEF and DREF distributions from Step 2, with equal weight assigned to each distribution | 0.36 | 0.44 | 1.3 | 3.8 | 6.1 |
|
| ||||||
| Step 4 | Preferred DDREF distribution obtained by truncating distribution from Step 3 by removing values <0.2 and >20 | 0.39 | 0.47 | 1.3 | 3.6 | 5.6 |