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. Author manuscript; available in PMC: 2018 Apr 27.
Published in final edited form as: Cell. 2016 Sep 8;166(6):1539–1552.e16. doi: 10.1016/j.cell.2016.08.027

Figure 1. Knockdown of Mitochondrial HSP70, hsp-6, Induces Cytosolic Heat Shock Response via UPRmt.

Figure 1

(A) hsp-6 and hsp-1 RNAi-induced cytosolic small heat shock protein expression. hsp-16.2p::GFP induction was measured by COPAS biosorter (bottom) (mean ± SD of three biological repeats; **p ≤ 0.01). EV, empty vector control RNAi.

(B) qPCR of UPRER and cytosolic HSR genes after hsp-6 RNAi (mean ± SD of three biological repeats).

(C) Cytosolic HSR induced by hsp-6 RNAi was dependent on both hsf-1 and UPRmt components. hsp-16.2p::GFP induction was measured by COPAS biosorter (bottom) (mean ± SD of three biological repeats; **p ≤ 0.001).

See also Figure S1 and Table S1.