Water intake on ethanol spout during abstinence. a,b) Total fluid intake (ml/kg) before (Pre-abstinence) and during abstinence for each of the three abstinence periods for a) non-heavy and b) heavy drinkers. Each data point represents a 28-day mean for each monkey and the bars represent a group mean ± SEM. Asterisks represent significant changes from pre-abstinence (Pre-abs), *p<0.05. c,d) Representative drinking patterns are shown for two monkeys: one that had evidence of extinction during abstinence (c, Monkey 209) and another that had no evidence of extinction (d, Monkey 208). Solid horizontal lines in both panels represent each monkey’s 12-month average ethanol intake prior to abstinence.