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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Oct 19;235(1):109–120. doi: 10.1007/s00213-017-4748-9

Fig. 4.

Fig. 4

Pituitary and adrenal hormone response to repeated abstinence during morning blood draws. a) ACTH and b) cortisol before abstinence (Pre-abs), 24 hours into abstinence, 21–22 days into abstinence, and within 1 week of resumed ethanol access (Post-abs). Each of these time points was matched for all abstinence phases (Abstinence 1–3). All data are presented as mean ± SEM. Asterisks indicate a significant change from Pre-abstinence. *p<0.05; **p<0.01; ***p<0.001. Hashes represent a significant group difference compared to the control group; ##p<0.01.