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Naringenin antioxidant activity-structure relationship. In red: Hydroxyl substituents (OH) that have high reactivity against reactive oxygen species and reactive nitrogen species. In green: 5,7-m-dihydroxy arrangement in the A-ring serves to stabilize the structure after donating electrons to free radicals. In blue: The association between 5-OH and 4-oxo substituents contributes to the chelation of compounds such as heavy metals.
