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. 2018 Apr 28;24(16):1766–1778. doi: 10.3748/wjg.v24.i16.1766

Figure 1.

Figure 1

Inhibition of CRH-R2 signaling aggravates symptoms of DSS-induced colitis in mice. A: Mice body weights measured for 16 d, and shown as percentage of weight change; B: Colon length; C: Representative photographs of colon lengths; D: DAI; E: Histological scores were evaluated on the 16th day; F: Representative images of hematoxylin-eosin staining histology. Data are presented as mean ± standard deviation, n = 6-10 per group, scale bar = 200 μm. aP < 0.001 vs control group; gP < 0.05, bP < 0.001 vs DSS group; cP < 0.001 vs Ucn2 group; hP < 0.05 vs TXYF-L group; fP < 0.01, dP < 0.001 vs TXYF-M group; iP < 0.05, eP < 0.001 vs TXYF-H group. CRH-R2: Corticotropin-releasing hormone-receptor 2; DAI: Disease activity index; DSS: Dextran sulfate sodium; TXYF: Tong-Xie-Yao-Fang.