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. 2018 Apr 28;24(16):1766–1778. doi: 10.3748/wjg.v24.i16.1766

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Inhibition of CRH-R2 signaling reduces epithelial cell proliferation in DSS-induced colitis. A-K: Representative images from Ki-67 immunoreactive sections; L: Quantification of Ki-67 immunohistochemistry data. Data presented as mean ± standard deviation, n = 6 per group, scale bar = 50 μm. ^cP < 0.05, ^dP < 0.01 vs control group; ^aP < 0.05, ^bP < 0.01 vs DSS group. ^fP < 0.01 vs Ucn2 group; ^eP < 0.05 vs TXYF-L group; ^gP < 0.01 vs TXYF-M group; ^hP < 0.01 vs TXYF-H group. CRH-R2: Corticotropin-releasing hormone-receptor 2; DSS: Dextran sulfate sodium; TXYF: Tong-Xie-Yao-Fang.