Table 1.
Significant KEGG pathways deduced from the differentially expressed genes in golgin-97-knockdown cells compared with control cells
| Term | Count | p-value | Genes |
|---|---|---|---|
| Rheumatoid arthritis | 14 | 3.2E-05 | ATP6V1C1, ICAM1, CCL3, CCL2, CCL20, IL18, TEK, IL1B, ITGB2, LTB, MMP1, TGFB1, IL1A, TGFB2 |
| Transcriptional misregulation in cancer | 17 | 8.3E-04 | MEF2C, PLAT, SLC45A3, LMO2, BAIAP3, RXRB, WHSC1, NR4A3, HIST1H3B, HIST1H3D, HIST1H3F, RUNX1, CD14, PLAU, HIST1H3H, CDK14, HIST1H3I |
| Cytokine-cytokine receptor interaction | 20 | 1.6E-03 | CSF3, CCL3, CCL2, TNFSF4, IL6ST, TNFRSF25, IL18, TNFSF15, IL7R, TGFB1, TGFB2, TNFRSF9, CXCL14, CCL20, IL1RAP, CXCR6, IL1B, EPOR, LTB, IL1A |
| Malaria | 8 | 2.7E-03 | CSF3, ICAM1, CCL2, IL18, IL1B, ITGB2, TGFB1, TGFB2 |
| MAPK signaling pathway | 19 | 1.1E-02 | MEF2C, LAMTOR3, FGFR3, TAOK1, CACNB1, PPM1A, TGFB1, FLNA, TGFB2, PLA2G4A, MAPT, RASGRP2, IL1B, PRKACB, CD14, MAP3K12, IL1A, RASA2, AKT2 |
| Legionellosis | 7 | 1.8E-02 | IL18, CASP7, IL1B, ITGB2, TLR5, SAR1B, CD14 |
| Alcoholism | 14 | 2.1E-02 | HIST1H2AB, HIST1H2AC, HIST1H4L, HDAC3, GNB1, HIST2H2BF, HIST2H2AC, HIST1H3B, HAT1, HIST1H3D, HIST1H2AK, HIST1H3F, HIST1H3H, HIST1H3I |
| PI3K-Akt signaling pathway | 22 | 2.8E-02 | CSF3, YWHAZ, FGFR3, PGF, TNC, ITGA2, IL7R, RPTOR, BRCA1, LAMA1, YWHAH, GNB1, ITGB8, COL6A3, TEK, COL6A2, COL6A1, EPOR, PRKAA1, EIF4E2, AKT2, F2R |
| Systemic lupus erythematosus | 11 | 3.6E-02 | HIST1H2AB, HIST1H2AC, HIST1H4L, HIST2H2BF, HIST2H2AC, HIST1H3B, HIST1H3D, HIST1H2AK, HIST1H3F, HIST1H3H, HIST1H3I |
| Inflammatory bowel disease (IBD) | 7 | 3.8E-02 | IL18, IL1B, TLR5, TGFB1, IL1A, STAT3, TGFB2 |
| Salmonella infection | 8 | 4.3E-02 | CCL3, IL18, WASF2, IL1B, TLR5, FLNA, CD14, IL1A |
| Hematopoietic cell lineage | 8 | 4.8E-02 | CSF3, GP1BB, IL1B, ITGA2, EPOR, IL7R, CD14, IL1A |
Underlines indicate genes transcriptionally regulated by NF-κB