Table 2.
Transcription factor enrichment analysis based on the 428 upregulated genes upon golgin-97 knockdown
| TF | Count | p value* | Genes |
|---|---|---|---|
| SP1 | 19 | 1.18E-03 | LAMA1, ICAM1, CCL2, CD14, TNC, EPOR, FBLN1, ALOX5, DNMT1, TGFB1, FGFR3, PLAU, IRF5, OXTR, CXCL14, PLAT, PADI1, ATP2A2, F2R |
| RELA | 11 | 2.30E-02 | IL1B, ICAM1, PLAU, CCL2, TNC, ALOX5, CD58, MMP1, IL1A, OXTR, TNFRSF9 |
| NFKB1 | 11 | 2.35E-02 | MMP1, IL1B, TNC, TNFRSF9, PLAU, ALOX5, IL1A, ICAM1, TGFB1, CD58, CCL2 |
| JUN | 9 | 1.70E-03 | IL1B, PLAT, CCL2, ITGB8, IL1A, TNC, OXTR, PLAU, MMP1 |
| SP3 | 8 | 1.11E-03 | FBLN1, F2R, LAMA1, PADI1, PLAT, CD14, ATP2A2, FGFR3 |
| STAT3 | 7 | 1.68E-02 | DNMT1, PGF, F2R, TGFB1, ICAM1, MMP1, CCL2 |
| NFKBIA | 4 | 3.42E-04 | ICAM1, IL1B, MMP1, CD58 |
| ATF2 | 4 | 2.63E-03 | PLAT, TGFB2, ITGB8, PLAU |
| TWIST1 | 4 | 3.67E-03 | F2R, ICAM1, MMP1, NR2F1 |
| KLF4 | 4 | 5.45E-03 | LAMA1, CD14, IL1B, CDKN1C |
| FOS | 4 | 2.03E-02 | OXTR, MMP1, IL1A, PLAU |
| PPARG | 4 | 3.26E-02 | ATP2A2, ANGPTL4, MMP1, ICAM1 |
| REL | 3 | 7.21E-03 | CCL2, IL1B, ICAM1 |
| TWIST2 | 3 | 1.03E-02 | ICAM1, F2R, NR2F1 |
| RARA | 3 | 1.15E-02 | ICAM1, RPTOR, PLAU |
| HDAC2 | 3 | 1.28E-02 | ALOX5, CCL2, DNMT1 |
| SMAD3 | 3 | 1.87E-02 | TNC, ANGPTL4, TGFB1 |
| ETS2 | 3 | 2.03E-02 | MMP1, ICAM1, TNC |
| ATF4 | 3 | 2.57E-02 | PLAU, CCL2, DISC1 |
| GATA3 | 3 | 3.19E-02 | TEK, MMP1, EPOR |
| IRF3 | 2 | 2.99E-02 | CCL2, IRF5 |
*Asterisk indicates a significant enrichment with a p-value< 0.05 as determined by Fisher’s exact test