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. 2018 Apr 27;19:129. doi: 10.1186/s12891-018-2050-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Treatment with PPARγ inhibitors ameliorated microstructural parameters and mineral apposition rate of trabecular bone. a Representative 3-D structure of femoral head of each group 6 weeks after the induction of osteonecrosis. b Quantitative analysis revealed significant reductions in BMD, BVF and Tb.Th and a significant increase in Tb.sp. in the model group compared with the normal group. Compared with the model group, the BADGE group exhibited significantly increased BMD and BVF (n = 5). c Representative tetracycline and calcein labelling images. d Quantitative analysis revealed a significantly increased mineral apposition rate in the BADGE group compared with the model group (n = 5). *P < 0.05 versus normal group; #P < 0.05 versus model group