FIG 7.

S mutations associated with viral escape from neutralizing MAbs. EMC was serially passaged in the presence of the indicated human and NHP neutralizing anti-S MAbs, singly or combined, and S mutations associated with antibody escape in the 10th (P10) or 20th (P20) passage were determined by S gene sequence analysis of 11 to 15 plaque isolates (P10 single MAb and P20 double MAb) or three independent population virus cultures (P10 double MAb). Percentages of viral isolates or cultures containing the indicated mutation are shown. MAb combinations that prevented the emergence of RBD mutations are shown in red.