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Poly(I·C) pretreatment impairs IFN-γ signaling in macrophages. Cultured BMDM were either treated with IFN-γ only (50 ng/ml) for 18 h or pretreated with poly(I·C) (5 μg/ml) for 4 or 12 h prior to treatment with IFN-γ for 18 h. Ciita, Cxcl9, and Cxcl10 mRNA levels were determined by quantitative real-time PCR in control and treated cultures as indicated. Data represent the means ± SEM from three independent experiments. *, P < 0.05 compared to IFN-γ-only treatment.
