FIG 7.

IFNAR abrogation on astrocytes enhances apoptosis of neurons and CD3⁺ cells in the CNS following infection. (A) Representative staining of apoptosis (anti-caspase 3) of neurons (anti-HuR) in brain cortex and brain stem at day 6 p.i. Arrows indicate caspase 3⁺ neurons, and arrowheads indicate nonneuronal caspase 3⁺ cells. (B) Apoptosis of T cells (anti-CD3) in mGFAPcre IFNAR^fl/fl mice. Arrows indicate caspase 3⁺ CD3⁺ cells. Scale bars, 50 μm and 20 μm at low and high magnifications, respectively.