FIG 9.
Abrogated IFNAR signaling in astrocytes leads to increased expression of proinflammatory factors. Brains from MHV A59-infected IFNARfl/fl and mGFAPcre IFNARfl/fl were analyzed for Cxcl1, Ccl2, Ccl5, and Il6 mRNA levels by quantitative RT-PCR. Data represent the means ± SEM for n = 4 mice per time point from one experiment representative of two independent experiments and were analyzed by the unpaired two-tailed Student t test. Asterisks indicate significance between IFNARfl/fl and mGFAPcre IFNARfl/fl mice: **, P < 0.01; ****, P < 0.0001.