TABLE 1.
Baseline characteristics of patients infected with M. abscessus belonging to CLA-resistant and -sensitive genotypes
| Characteristica | Valueb |
P value | |
|---|---|---|---|
| CLA-resistant group (n = 69) | CLA-sensitive group (n = 31) | ||
| Median age (IQR) (yr) | 58 (44–66) | 56 (32–64) | 0.562 |
| Males | 26 (37.7) | 17 (54.8) | 0.107 |
| BMI (mean ± SD) (kg/m2) | 19.93 ± 0.37 | 19.69 ± 0.57 | 0.729 |
| Underlying disease | |||
| Prior tuberculosisc | 29 (42.0) | 16 (51.6) | 0.373 |
| COPD | 1 (1.4) | 2 (6.5) | 0.226 |
| Hypertension | 11 (15.9) | 3 (9.7) | 0.601 |
| Diabetes | 2 (2.9) | 4 (12.9) | 0.135 |
| CHD | 4 (5.8) | 0 (0) | 0.414 |
| Malignancy | 3 (4.3) | 0 (0) | 0.550 |
| History of surgery | 3 (4.3) | 1 (3.2) | 1 |
| Symptoms | |||
| Cough | 55 (79.7) | 25 (80.6) | 0.914 |
| Sputum | 69 (100.0) | 31 (100.0) | 1 |
| Fever | 15 (21.7) | 4 (12.9) | 0.298 |
| Hemoptysis | 22 (31.9) | 4 (12.9) | 0.045 |
| Radiographic features | |||
| Extent | 0.404 | ||
| Bilateral involvement | 58 (84.0) | 28 (90.3) | |
| Unilateral involvement | 11 (15.9) | 3 (9.7) | |
| Median no. of lobes (IQR) | 4 (3–6) | 4 (2–6) | 0.419 |
| Disease pattern | |||
| Bronchiectasis | 66 (95.7) | 29 (93.4) | 0.655 |
| Cavity | 50 (72.5) | 8 (25.8) | <0.001 |
| Nodules (diam < 1 cm) | 38 (55.0) | 19 (61.3) | 0.561 |
| Nodules (diam > 1 cm) | 39 (56.5) | 16 (51.6) | 0.648 |
| Tree-in-bud pattern | 16 (23.2) | 14 (45.2) | 0.027 |
| Initial AFB smear positivity | 28 (40.6) | 10 (32.3) | 0.428 |
| Initial morphotype | 0.770 | ||
| Rough | 40 (58.0) | 17 (54.8) | |
| Smooth | 29 (42.0) | 14 (45.2) | |
a
COPD, chronic obstructive pulmonary disease; CHD, coronary heart disease; AFB, acid-fast bacilli; IQR, interquartile range.
b
Data are the numbers (%) of patients found in the CLA-resistant and -sensitive genotype groups unless otherwise indicated.
c
Patients treated for tuberculosis prior to the diagnosis of M. abscessus lung disease.