FIG 2.

Epitopes determined by CLIPS analysis mapped onto the IBV trimeric HA structure. IBV-specific MAbs (2 from the literature and 4 from this study, with the germ line families being noted) all bind to the HA stalk region, with the specific peptide sequences recognized by each MAb being listed (the numbering scheme is based on the HA from B/Lee/40/1940). Those amino acids are shown in red using a space-filling representation for the surface, with a ribbon representation being used for the backbone. For clarity, the MAb-binding residues on only one of the three monomers that make up the HA homotrimer are shown. Graphic images were made using the PyMOL molecular graphics system (Schrödinger LLC).