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Drug delivery for CL. (A) Progression pathway during lead optimization of drugs as potential topical treatment for CL. (B) Histology of BALB/c mouse skin infected with L. major. The schematic (A) shows the route of the active drug through Leishmania-infected BALB/c mouse skin before reaching the Leishmania amastigotes situated in phagolysosome of dermal macrophages (B). PK, pharmacokinetics.
