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Papp values with and without GF918 and AQ for the MDCKII-hMDR1 cell assay
| Compound |
Papp (nm/s) |
AQ | |
|---|---|---|---|
| Without GF918 | With GF918 | ||
| Amprenavir | 58.3 | 378 | 0.846 |
| Propranolol | 395 | 441 | 0.104 |
| LSH001 | 583 | 599 | 0.027 |
| LSH002 | 16.5 | 32.5 | 0.492 |
| LSH003 | 626 | 635 | 0.014 |
| LSH023 | 605 | 593 | −0.020 |
| LSH024 | 236 | 314 | 0.248 |
| LSH025 | 322 | 349 | 0.077 |
| LSH026 | 652 | 655 | 0.005 |
| LSH027 | 209 | 247 | 0.154 |
| LSH028 | 397 | 424 | 0.064 |
| LSH029 | 229 | 268 | 0.146 |
| LSH030 | 436 | 524 | 0.168 |
| LSH032 | 232 | 327 | 0.291 |
| LSH033 | 404 | 482 | 0.162 |
| LSH034 | 543 | 538 | −0.009 |
