TABLE 6.
Permeation parameters: flux and lag time when using RHE and BALB/c mouse skin under the same conditions and BALB/c mouse skin when applying a low volumea
| Strain | Testosterone |
LSH001 |
LSH002 |
LSH003 |
||||
|---|---|---|---|---|---|---|---|---|
| Flux (ng/cm2/h) | Lag time (h) | Flux (ng/cm2/h) | Lag time (h) | Flux (ng/cm2/h) | Lag time (h) | Flux (ng/cm2/h) | Lag time (h) | |
| RHE | 28.0 ± 0.8 | 0.7 ± 0.1 | 21.8 ± 0.1 | 2.2 ± 0.1 | 143.9 ± 44.2 | 1.7 ± 0.8 | 45.1 ± 5.9 | 2.1 ± 0.1 |
| BALB/c | 2.2 ± 0.8 | 1.1 ± 0.6 | 6.6 ± 0.3b | 2.4 ± 0.4 | 35.8 ± 0.9b | 2.8 ± 0.3 | 8.0 ± 1.5b | 2.5 ± 0.3 |
| BALB/c Low vol | 88.7 ± 8.8 | 2.7 ± 0.5* | 13.5 ± 8.7b | 2.7 ± 0.7 | 71.8 ± 18.0 | 2.7 ± 0.9 | ||
a
Data represent the mean ± SD (n = 3), unless indicated otherwise.
b
Data represent the mean ± SD (n = 2).