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Metabolic stability of BHBM and D13 in human and mouse liver microsomes
| Compound and species | t1/2 (min) | CLinta (μl/min/mg protein) |
|---|---|---|
| Verapamil | ||
| Human | 12.19 | 113.72 |
| Mouse | 9.15 | 151.48 |
| BHBM | ||
| Human | 48.81 | 28.40 |
| Mouse | 7.33 | 189.21 |
| D13 | ||
| Human | 103.09 | 13.45 |
| Mouse | 88.58 | 15.65 |
CLint, intrinsic clearance.
