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Efficacy of PC1244 on sterol 14α-demethylase (CYP51) activity. (A, B) Type II azole binding spectra for A. fumigatus CYP51A (AfCYP51A) (A) and CYP51B (AfCYP51B) (B). Each experiment was performed 4 to 6 times, although only one replicate is shown, (C, D) IC50s of posaconazole (●) and PC1244 (○). Mean relative velocity values with standard deviations are shown for A. fumigatus CYP51A (C) and CYP51B (D).
