TABLE 3.
Sterol composition of A. fumigatus isolates treated with either posaconazole or PC1244
| Treatment and sterol | Sterol compositiona (%) after treatment with DMSO or the indicated compound at the following concn (μg/ml): |
|||||
|---|---|---|---|---|---|---|
| DMSO | 0.0001 | 0.001 | 0.01 | 0.1 | 1 | |
| Posaconazole | ||||||
| Ergosterol | 100 ± 0 | 94.5 ± 0.1 | 87.2 ± 0.7 | 74.7 ± 0.8 | 67.8 ± 0.3 | 67.4 ± 1.5 |
| Ergost-5,7-dienol | 0 | 3.3 ± 1.9 | 3.9 ± 0.6 | 0 | 0 | 0 |
| Lanosterol | 0 | 0 | 3.0 ± 0.9 | 7.0 ± 0.3 | 8.8 ± 0.5 | 8.8 ± 0.4 |
| Eburicol | 0 | 2.2 ± 1.2 | 5.9 ± 0.5 | 18.3 ± 1.1 | 23.4 ± 0.8 | 23.8 ± 1.3 |
| PC1244 | ||||||
| Ergosterol | 100 ± 0 | 91.3 ± 0.1 | 89.2 ± 0.2 | 76.8 ± 2.6 | 61.0 ± 1.6 | 58.7 ± 2.2 |
| Ergost-5,7-dienol | 0 | 4.6 ± 1.8 | 4.6 ± 0.8 | 0 | 0 | 0 |
| Lanosterol | 0 | 1.7 ± 0.7 | 2.8 ± 0.6 | 8.5 ± 1.1 | 12.3 ± 0.8 | 13.1 ± 0.9 |
| Eburicol | 0 | 2.5 ± 1.1 | 3.4 ± 1.2 | 14.7 ± 1.5 | 26.7 ± 0.8 | 28.2 ± 1.3 |
a
The values are the means from three biological replicates ± standard deviations of the means.