TABLE 2.
Strain or antifungal drug | MIC range (μg/ml) | MIC50/MIC90 (μg/ml) | Geometric mean (μg/ml) | MICs (μg/ml)a |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
64 | 32 | 16 | 8 | 4 | 0.5 | 0.25 | 0.125 | 0.06 | 0.03 | 0.015 | 0.008 | 0.004 | 0.002 | 0.001 | 0.0005 | 0.0002 | 0.0001 | ||||
All strains (n = 120) | |||||||||||||||||||||
Efinaconazole | 0.002–0.06 | 0.008/0.016 | 0.007 | 4 | 2 | 11 | 61 | 36 | 6 | ||||||||||||
Lanoconazole | 0.001–0.008 | 0.002/0.004 | 0.002 | 6 | 21 | 82 | 11 | ||||||||||||||
Luliconazole | 0.0005–0.004 | 0.0005/0.001 | 0.0005 | 2 | 4 | 22 | 80 | 10 | 2 | ||||||||||||
Fluconazole | 8–64 | 16/32 | 12.77 | 5 | 8 | 52 | 53 | 2 | |||||||||||||
Itraconazole | 0.03–0.5 | 0.125/0.25 | 0.095 | 3 | 10 | 56 | 43 | 8 | |||||||||||||
Terbinafine | 0.004–0.125 | 0.015/0.0165 | 0.011 | 1 | 3 | 8 | 50 | 53 | 5 | ||||||||||||
T. interdigitale (n = 66) | |||||||||||||||||||||
Efinaconazole | 0.002–0.006 | 0.008/0.016 | 0.008 | 3 | 1 | 9 | 41 | 10 | 2 | ||||||||||||
Lanoconazole | 0.001–0.008 | 0.002/0.004 | 0.002 | 4 | 10 | 48 | 4 | ||||||||||||||
Luliconazole | 0.0002–0.004 | 0.0005/0.001 | 0.0006 | 2 | 2 | 16 | 41 | 5 | |||||||||||||
Fluconazole | 4–64 | 8/16 | 11.07 | 2 | 3 | 21 | 38 | 2 | |||||||||||||
Itraconazole | 0.03–0.5 | 0.12/0.25 | 0.111 | 3 | 7 | 38 | 15 | 3 | |||||||||||||
Terbinafine | 0.004–0.12 | 0.015/0.03 | 0.013 | 1 | 2 | 6 | 35 | 20 | 2 | ||||||||||||
T. rubrum (n = 54) | |||||||||||||||||||||
Efinaconazole | 0.002–0.06 | 0.004/0.008 | 0.005 | 1 | 1 | 2 | 20 | 26 | 4 | ||||||||||||
Lanoconazole | 0.002–0.008 | 0.002/0.004 | 0.002 | 2 | 11 | 34 | 7 | ||||||||||||||
Luliconazole | 0.0005–0.002 | 0.0005/0.001 | 0.0004 | 2 | 6 | 39 | 5 | 2 | |||||||||||||
Fluconazole | 8–64 | 16/32 | 15.19 | 3 | 5 | 31 | 15 | ||||||||||||||
Itraconazole | 0.03–0.25 | 0.06/0.125 | 0.077 | 3 | 18 | 28 | 5 | ||||||||||||||
Terbinafine | 0.004–0.06 | 0.008/0.016 | 0.009 | 1 | 2 | 15 | 33 | 3 |
Numbers in boldface are modal values.