TABLE 2.
Final parameter estimates and variances from the population analysis, including uncertainty and shrinkagea
| Parameter | Parameter description | Final model |
Reduced model |
||
|---|---|---|---|---|---|
| Estimate | % RSE (% SHR) | Estimate | % RSE (% SHR) | ||
| CL (liters/h) | Elimination clearance | 3.09 | 11 | ||
| eCLCrb (ml/min) | Estimated creatinine clearance | 0.0460 | 6.7 | ||
| Vc (liters) | Central distribution vol | 8.31 | 9.0 | 8.19 | 8.5 |
| Q (liters/h) | Intercompartmental clearance | 8.52 | 31 | 9.34 | 28 |
| Vp (liters) | Peripheral distribution vol | 6.99 | 15 | 7.67 | 15 |
| fu | Fraction unbound in SCT | 0.790 | 4.6 | 0.782 | 4.2 |
| %CV | |||||
| CL | Variability in CL | 18.9 | 17 (0) | 33.6 | 17 (0) |
| Vc | Variability in Vc | 25.1 | 25 (7) | 24.8 | 24 (11) |
| Q | Variability in Q | 64.6 | 16 (6) | 72.8 | 23 (7) |
| ERR | Proportional residual error | 19.9 | 7.2 (4) | 21.4 | 11 (4) |
a
Abbreviations: %CV, percent coefficient of variation; RSE, relative standard error; SCT, subcutaneous adipose tissue; SHR, shrinkage.
b
eCLcr was determined using the Cockcroft-Gault formula.