TABLE 2.

In vitro susceptibilities of 10 antifungal drugs against 126 Fusarium isolates from different species complexes

Source and antifungal agent	Susceptibility (n) at MIC/MECa (μg/ml) of:
	0.001	0.002	0.004	0.008	0.016	0.032	0.064	0.125	0.25	0.5	1	2	4	8	≥16
Fusarium, clinical (n = 47)
Luliconazole	10	6	8	9	8	5		1
Lanoconazole	4	6	4	4	7	8	9	3	1		1
Efinaconazole			1				1	1	1	6	22	15
Voriconazole								1	1	2	9	16	15	2	1
Itraconazole									1		1	1	1	2	42
Amphotericin B					1			2	1	3	8	14	7	6	5
Natamycin								2	1	5	20	19
Caspofungin				1	1			3			1	1	2	38
Micafungin	1			4	1	5	1	1	2	2	2	4		24
Anidulafungin									1	1		2	3	40
Fusarium, environmental (n = 79)
Luliconazole	16	14	6	10	15	11	5	2
Lanoconazole	5	10	12	14	10	13	4	6	4	1
Efinaconazole									3	18	54	4
Voriconazole								2	9	19	21	18	12	1
Itraconazole								1	1		1	3	5	12	56
Amphotericin B								1		10	14	22	20	7	5
Natamycin								1	5	10	35	24	3	1
Caspofungin				1	1	1		1			2	7	16	50
Micafungin				1	2		1	2	2	16	12	11	14	18
Anidulafungin										11	2	3		63
F. fujikuroi complex (n = 94)
Luliconazole	19	13	12	12	20	12	5	1
Lanoconazole	7	12	14	13	12	14	11	6	3	1	1
Efinaconazole							1		4	21	53	15
Voriconazole								3	6	20	24	24	17
Itraconazole								1		2	2	3	4	14	68
Amphotericin B					1			1		12	17	25	23	8	7
Natamycin								1	5	13	40	31	4
Caspofungin				1	1	1		2			1	7	37	44
Micafungin	1			3	2	3		2	3	17	12	12	12	27
Anidulafungin									1	2	1	3	13	9	65
F. solani complex (n = 14)
Luliconazole		3	1	1	3	3	1	2
Lanoconazole		1		1	2	4	3	1	2
Efinaconazole										1	11	2
Voriconazole										2	3	3	3	3
Itraconazole													1		13
Amphotericin B								2	1		1	4	2	3
Natamycin								2		2	5	4		1
Caspofungin				1								2		11
Micafungin					1				1	2	1	2		7
Anidulafungin										1	1			12
F. oxysporum complex (n = 11)
Luliconazole	4	2	2	3
Lanoconazole	1	3	2		1	1		3
Efinaconazole			1					1		1	7	1
Voriconazole											2	4	5
Itraconazole															11
Amphotericin B											1	4	1	2	3
Natamycin									1		3	7
Caspofungin					1		2	1					1	8
Micafungin				2					1			1	1	4
Anidulafungin										2		2		7
F. graminearum complex (n = 1)
Luliconazole	1
Lanoconazole				1							1
Efinaconazole											1
Voriconazole												1
Itraconazole															1
Amphotericin B													1
Natamycin												1
Caspofungin														1
Micafungin														1
Anidulafungin														1
F. lateritium complex (n = 1)
Luliconazole				1
Lanoconazole				1
Efinaconazole											1
Voriconazole												1
Itraconazole												1
Amphotericin B											1
Natamycin												1
Caspofungin														1
Micafungin														1
Anidulafungin														1

^aThe mode in each row is in boldface. MEC only for echinocandins caspofungin, micafungin, and anidulafungin.