TABLE 2.
Salient features of dermatophytosis due to azole- and/or allylamine-resistant Trichophyton speciesa
| Patient ID | Organism | NCCPF no./GenBank accession no. | Antifungal exposure | Relapse | MIC (μg/ml) |
Mutation | ||
|---|---|---|---|---|---|---|---|---|
| Terbinafine | Naftifine | Fluconazole | ||||||
| 12 | T. interdigitale | 800032/MG587085 | Clotrimazole + miconazole | Yes | 2 | 4 | 2 | No |
| 29 | T. interdigitale | 800033/MG587086 | No | No | 16 | >16 | 16 | No |
| 68 | T. interdigitale | 800022/KX906451 | No | Yes | 16 | >16 | 8 | F397L |
| 89 | T. interdigitale | 800023/KX906452 | No | No | 16 | >16 | 32 | F397L |
| 93 | T. interdigitale | 800024/KX906453 | No | No | 32 | >16 | 2 | No |
| 98 | T. interdigitale | 800040/KX906463 | Terbinafine | Yes | 4 | 8 | 2 | F397L |
| 106 | T. interdigitale | 800030/KX906456 | Herbal remedies | No | 2 | 1 | 4 | No |
| 125 | T. interdigitale | 800025/KX906454 | No | Yes | 16 | >16 | 32 | No |
| 139 | T. interdigitale | 800026/KX906455 | No | No | 16 | 8 | 4 | F397L |
| 143 | T. interdigitale | 800027/MG587087 | Herbal remedies | No | 4 | >16 | 8 | No |
| 145 | T. interdigitale | 800028/MG587088 | Fluconazole + luliconazole | Yes | 4 | 8 | 8 | No |
| 157 | T. interdigitale | 800050/MG587089 | Terbinafine | Yes | 16 | 8 | 8 | No |
| 173 | T. interdigitale | 800029/MG587090 | Not known | No | 16 | 1 | 4 | No |
| 174 | T. interdigitale | 800031/MG587091 | Not known | Yes | 8 | 16 | 16 | No |
| 198 | T. interdigitale | 800051/MG587092 | No | No | 32 | 16 | 32 | No |
| 46 | T. rubrum | 900038/KX906447 | Fluconazole | Yes | 2 | 4 | 2 | No |
| 118 | T. rubrum | 900039/KX906448 | Clotrimazole + terbinafine | Yes | 16 | 0.0625 | 8 | No |
| 126 | T. rubrum | 900042/MG587093 | No | No | 2 | 1 | 4 | No |
| 137 | T. rubrum | 900040/KX906449 | Fluconazole | Yes | 16 | 8 | 4 | F397L |
| 156 | T. rubrum | 900041/KX906473 | Luliconazole | No | 8 | >16 | 4 | F397L |
a
ID, identifier; NCCPF, National Culture Collection of Pathogenic Fungi.