TABLE 2.
Pharmacokinetic parameters of 2,000 mg ertapenem in tuberculosis patients
| Pharmacokinetic parametera | Median (IQR) |
|---|---|
| AUC0–∞ (h · mg/liter) | 2032 (1751–2346) |
| CL12 (liters/h) | 1.941 (0.979–2.817) |
| V1 (liters) | 1.514 (1.064–2.210) |
| V2 (liters) | 2.984 (1.912–3.428) |
| Vss (liters) | 4.560 (3.857–5.160) |
| k10 (/h) | 0.677 (0.539–0.863) |
| k12 (/h) | 1.690 (0.482–2.666) |
| k21 (/h) | 0.718 (0.530–0.863) |
| t1/2 1 (h) | 0.225 (0.162–0.519) |
| t1/2 2 (h) | 3.859 (3.620–4.301) |
| MRT (h) | 3.991 (3.840–5.494) |
| MIT (h) | 0.296 (0.250–0.342) |
a
AUC0–∞, area under the concentration-time curve from 0 h to infinity; CL12, intercompartmental clearance; V1, volume of distribution of the central compartment; V2, volume of distribution in the peripheral compartment; Vss, volume of distribution at steady-state; k12 and k21, first-order intercompartmental transfer rate constants between the central and peripheral compartments; k10, elimination rate constant; t1/2 1 and 2, distribution and elimination half-lives; MRT, mean resident time; MIT, mean input time.