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. 2018 Apr 27;8:6639. doi: 10.1038/s41598-018-25094-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Normal skin DC function in Il31^−/− mice. (a) The proportion of FITC-positive cells among 7-AAD-negative MHC class II^hi CD11c⁺ cells in draining LNs from wild-type (n = 4) and Il31^−/− (n = 4) mice 24 hours after sensitization with FITC or vehicle alone was determined by flow cytometry. Representative flow cytometric data are shown. Shaded areas = LNs obtained from the vehicle-treated left ear (lower number [%]), and solid lines = LNs obtained from the FITC-treated right ear (upper number [%]). The data show the mean + SEM. (b) The expression levels of CD86, CD40 and OX40L on 7-AAD-negative MHC class II^hi CD11c⁺ FITC-positive cells in draining LNs from wild-type and Il31^−/− mice 24 hours after sensitization with FITC or vehicle alone were determined by flow cytometry. Representative flow cytometric data are shown for wild-type (n = 6) and Il31^−/− (n = 4) mice. Shaded areas = isotype-matched control Ig staining, and solid lines = specific mAb staining.