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. 2018 Apr 27;8:6640. doi: 10.1038/s41598-018-24622-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative figure of tissue-cleared hearts and light-sheet images. (A) Sample of a mouse heart before tissue-clearing process (B) Cleared heart samples of control (left) and ischemic hearts (right). Suture used for the permanent ligation of left anterior descending artery can be seen (black arrow) (C) Light-sheet image of control (left) and ischemic (right) hearts. Infarcted area with thinning is observed (white arrow) (D) Image processing of raw light-sheet images (upper panel) using Sobel filters (lower panel) (E) 3D reconstruction of the entire heart from light-sheet images.