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. 2018 Apr 27;9:1693. doi: 10.1038/s41467-018-04114-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Ebselen does not prevent heterodimer formation with hCCS. Size exclusion chromatograms showing how ebselen binding to C57/146A SOD1 promotes dimerization (blue dashed line to red dashed line) but does not inhibit heterodimeric complex formation with wild-type hCCS, which exists in homodimeric state prior to complexation