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. 2018 Apr 27;9:1691. doi: 10.1038/s41467-018-04001-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Copy number alterations detection of CTCs and cfDNA in multiple myeloma. a MM-related copy number alterations (CNAs—purple box) were detected in three patients with matched cfDNA and CTC samples via ULP-WGS. Amplification (red), deletion (green), and copy neutral (blue) are indicated. b Comparison of normalized copy ratios (log2) among cfDNA ULP-WGS, CTC ULP-WGS, and tumor biopsy WES in MM_2205. Amplification (red), deletion (green), and copy neutral (blue) are indicated