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. 2018 Apr 27;8:6668. doi: 10.1038/s41598-018-25085-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RNA-Seq analysis following long-term exposure to AgNPs. BEAS-2B cells were exposed for 6 weeks to AgNPs at 1 µg/mL and RNA-seq was performed on triplicate samples. Using the IPA tool, pathway analysis of the DEGs was conducted. Heatmaps displaying the gene expression changes in the Ag10 vs Control samples were generated for the hepatic fibrosis pathway (A) and regulation epithelial-mesenchymal transition pathway (B). (C) Upstream regulator analysis was performed using the IPA software tool for Ag10 and a network was generated for the predicted activated transcription factors, ZEB1, TWIST1, SNAI1.