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Effect of BoNT on compound 48/80 induced mast cell degranulation in human (hMC) and mouse mast cell culture (mMC): Mast cell β-hexosaminidase release (as index of mast cell degranulation) following compound 48/80 (48/80, 10 μg/mL) and chloroquine (CQ) (A); mast cell β-hexosaminidase release induced by 48/80 (1μg/mL) 24 h after treatment with 0.5 U of BoNT/A1 or BoNT/B1 in murine mast cell culture (B) and in human mast cell culture (C). *** p < 0.001 compared to other groups.
