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. 2018 Apr 5;10(4):150. doi: 10.3390/toxins10040150

Table 1.

Summary of the serum toxicokinetics of FB1 administered iv (FB1iv) as a single bolus of 139 nmol·kg·BW−1 in barrows (n = 6).

FB1−m
Animal 4 5 15 18 23 29 Mean SD
BW (kg) 31.0 33.0 35.0 35.4 32.3 35.0 33.6 1.8
FB1 (nmol·kg·BW−1) 139 139 139 139 139 139 139 0
A (nmol·L−1) 410.0 200.3 238.7 766.9 1022.9 573.7 535.4 319.0
α (h−1) 14.9 5.6 7.4 16.4 12.2 8.1 10.8 4.4
B (nmol·L−1) 94.8 7.4 10.3 194.0 440.7 119.9 144.5 161.3
β (h−1) 2.8 0.6 0.8 2.2 2.4 1.5 1.7 0.9
t1/2α (h) 0.05 0.12 0.09 0.04 0.06 0.09 0.08 0.03
t1/2β (h) 0.25 1.26 0.83 0.32 0.29 0.47 0.57 0.40
Vd (L·kg·BW−1) 0.8 5.1 3.7 0.5 0.2 0.6 1.8 2.1
Cl (L·kg·BW−1·h−1) 2.3 2.8 3.1 1.0 0.5 0.9 1.8 1.1
AUC (nmol·L−1·h) 61 49 45 135 266 152 118 86
RSD (nmol·L−1) 1.9 1.4 1.7 3.1 3.6 5.8 2.9 1.7
r2 0.998 0.999 0.997 0.998 0.999 0.998 0.998 0.001
FB1+m
A (nmol·L−1) 483.1 214.9 260.4 843.1 1122.1 636.0 593 349
α (h−1) 16.0 6.0 7.8 15.9 12.1 8.1 11.0 4.3
B (nmol·L−1) 98.1 8.7 10.6 205.9 481.1 135.7 156.7 175.9
β (h−1) 2.9 0.6 0.7 2.1 2.4 1.5 1.7 0.9
t1/2α (h) 0.04 0.12 0.09 0.04 0.06 0.09 0.07 0.03
t1/2β (h) 0.24 1.22 0.94 0.33 0.29 0.46 0.58 0.40
Vd (L·kg·BW−1) 0.8 4.8 3.9 0.4 0.2 0.6 1.8 2.0
Cl (L·kg·BW−1·h−1) 2.2 2.7 2.9 0.9 0.5 0.8 1.7 1.1
AUC (nmol·L−1·h) 64 51 48 150 293 169 129 96
AUCFB1−m% (%) 95 96 93 90 91 90 93 3
RSD (nMol·L−1) 2.0 1.4 1.8 3.6 4.3 6.0 3.2 1.8
r2 0.998 0.998 0.997 0.999 0.999 0.997 0.998 0.001

BW = body weight; −m = FB1 alone; +m = FB1 plus metabolites: HFB1, pHFB1a, pHFB1b; A, B = initial concentrations for distribution and elimination, respectively, at t = 0; α and β = rate constants of distribution or elimination phase; t1/2α and t1/2β = half-lives of distribution and elimination, respectively; Vd = apparent volume of distribution, Cl = serum clearance, AUC = area under the time vs. concentration curve; AUCFB1−m% = AUC of FB1 alone without metabolites compared to FB1 plus sum of metabolites in %; RSD = residual standard deviation of the regression; r2 = coefficient of determination; SD = standard deviation. Data were evaluated with Students t-test for independent data sorted in groups (for parametric data).