Table 3.

Summary of the serum toxicokinetics of FB1 administered orally (FUMpo) at 3377 nmol·kg·BW⁻¹ (FB1) + 1367 nmol·kg·BW⁻¹ (FB2) + 584 nmol·kg·BW⁻¹ (FB3) in barrows (n = 4).

FB1−m
Animal		2	14	17	25	Mean	SD
BW (kg)		31.6	37.5	35.5	32.0	34.2	2.8
FB1 (nmol·kg·BW−1)		3683	3103	3278	3637	3425	281
ka (h−1)		0.15	2.22	0.25	0.08	0.68	1.03
ke (h−1)		0.03	0.02	0.04	0.08	0.04	0.03
C0 (nmol·L−1)		3.6	1.3	3.3	5.5	3.4	1.7
cmax (nmol·L−1)		2.5	1.3	2.4	2.0	2.1	0.5
tmax (h)		13.9	2.2	8.7	13.1	9.5	5.4
t1/2ka (h)		4.6	0.3	2.7	9.1	4.2	3.7
t1/2ke (h)		26.0	38.5	17.7	9.1	22.8	12.5
Vd (L·kg·BW−1)		7.3	10.1	6.5	10.7	8.7	2.1
Cl (L·kg·BW−1·h−1)		0.2	0.2	0.3	0.8	0.4	0.3
AUC (nmol·L−1·h)		135	73	85	71	91	30
FAUC (%)		4.3	2.8	3.1	2.3	3.1	0.8
F (%)		0.007	0.004	0.007	0.016	0.009	0.005
MRT (h)		33.6	28.4	21.2	18.5	25.4	6.9
RSD (nmol·L−1)		0.5	0.3	0.4	0.4	0.4	0.1
r2		0.684	0.655	0.764	0.672	0.694	0.048
FB1+m
ka (h−1)	0.11		0.26	0.11	0.07	0.14	0.08
ke (h−1)	0.03		0.02	0.04	0.07	0.04	0.02
c0 (nmol·L−1)	9.0		2.8	5.9	5.8	5.9	2.5
cmax (nmol·L−1)	5.7		2.3	3.2	2.1	3.3	1.7
tmax (h)	16.6		10.6	13.6	13.7	13.6	2.5
t1/2ka (h)	6.2		2.7	6.1	9.5	6.1	2.8
t1/2ke (h)	25.3		32.4	15.5	9.5	20.7	10.2
Vd (L·kg·BW−1)	1.7		7.4	10.3	11.3	7.7	4.3
Cl (L·kg·BW−1·h−1)	0.05		0.16	0.46	0.83	0.4	0.3
AUC (nmol·L−1·h)	328		132	132	80	168	109
AUCFUM-m% (%)	41.3		55.0	64.4	89.5	62.6	20.3
FAUC (%)	9.6		4.6	4.3	2.4	5.2	3.1
F	0.004		0.007	0.019	0.018	0.012	0.008
MRT (h)	34.7		31.5	25.0	23.2	28.6	5.4
RSD (nmol·L−1)	1.2		0.5	0.5	0.5	0.7	0.4
r2	0.464		0.604	0.783	0.655	0.627	0.132

BW = body weight; −m = FB1 alone; +m = FB1 plus metabolites: HFB1, pHFB1a, pHFB1b; k_a and k_e = rate constants of absorption or elimination phase; c₀ = initial concentration corresponding to elimination; c_max = maximum serum concentration, t_max = time corresponding to C_max; t_1/2ka and t_1/2ke = half-lives of absorption and elimination, respectively; V_d = apparent volume of distribution, Cl = serum clearance, AUC = area under the time vs. concentration curve; F = fraction of the toxin appearing in the systemic circulation (%); F_AUC = AUC after po administration of the toxin divided by the mean AUC after iv administration; dose-corrected for the respective doses (see Table 4) and multiplied by 100; MRT = mean residence time of toxin in the invaded compartment; RSD = residual standard deviation; r² = coefficient of determination; AUC_FUM-m% = AUC of FB1 alone without m compared to FB1 plus sum of metabolites in %; SD = standard deviation. Data were evaluated with Students t-test for independent data sorted in groups (for parametric data).