Table 4.
Summary of the area under the curve (AUC) and bioavailability (F) of FB1 alone (FB1−m) and the sum of FB1 and metabolites (FB1+m) in serum of pigs administered a single bolus of 120 mg FB1 + 48 mg FB2 + 14 mg FB3/kg diet po with fumonisin esterase (FumDpo, 240 U/kg diet, n = 6) or without (FUMpo, n = 4).
| FB1−m | FB1+m | |||||
|---|---|---|---|---|---|---|
| FUMpo | FumDpo | p-Value | FUMpo | FumDpo | p-Value | |
| AUC (nMol·L−1·h) | 91.0 (12) | 9.0 (15.8) | <0.01 | 168.0 (45) | 27.7 (20.0) | 0.01 |
| FAUC (%); absolute | 3.1 (0.4) | 0.3 (0.6) | <0.01 | 5.2 (1.3) | 0.8 (0.6) | 0.01 |
AUC = area under the time vs. concentration curve, calculated using the trapezoid method (nmol·L−1·h); FAUC, absolute = AUC after po administration of the toxin divided by the mean AUC after iv administration; dose-corrected (see Table 1). Data are presented as means (±SD) and comparison between treatments was performed with a Student’s t-test.