Table 5.
Cumulative urinary and fecal excretion of FB1 alone (FB1−m) and the sum of FB1 and its metabolites (FB1+m) after 120 h as percentage of exposure (median, n = 6/group).
| Urinary Excretion % | Fecal Excretion % | |||
|---|---|---|---|---|
| FB1−m | FB1+m | FB1−m | FB1+m | |
| FB1iv | 10.56 a (8.33–13.44) |
11.80 a (10.33–14.35) |
1.88 a (0.00–3.76) |
8.57 a (0.00–13.53) |
| HFB1iv | <LOD | 3.95 b (0.67–6.48) |
0.00 a (0.00–1.71) |
0.40 b (0.00–4.04) |
| FUMpo | 0.24 c (0.12–0.56) |
0.56 c (0.26–1.56) |
25.05 b (8.51–55.51) |
72.92 c (52.49–93.66) |
| FumDpo | 0.012 b (0.001–0.061) |
0.234 c (0.045–1.256) |
1.34 a,c (0.22–2.26) |
58.81 c (51.34–80.05) |
−m = FB1 alone; +m = FB1 plus metabolites: HFB1, pHFB1a, pHFB1b; Data (median, min-max) with unlike superscripts in one column are significantly different from each other (Mann-Whitney-U-test, p < 0.05).