Figure 2.
Tissue pathogenesis is induced by EV-V, but not EV-R, in hSCARB2-Tg mice.Serial sections of spinal cord and the surrounding muscle from naïve mice and hSCARB2-Tg mice challenged with 5 × 106 pfu of EV-V or EV-R were obtained on day 4 pi and then stained with dyes or antibodies. Representative images of H/E-stained (A) spinal and (B) muscle sections are shown. (C) Representative images of VP2 of EV71 in respective muscle sections that were stained with Mab979, a VP2-specific antibody. All images were obtained at 10× magnification, and the scale bars represent 200 µm. Similar results were obtained from two independent experiments with four mice per group; one is shown.