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. 2018 Mar 28;10(4):93. doi: 10.3390/cancers10040093

Figure 2.

Figure 2

The described JAK/STAT/BATF/MYC signalling cascade in Classical Hodgkin Lymphoma (CHL) and Anaplastic Large Cell Lymphoma (ALCL). JAK2 activation, via IL-13 stimulation, results in the phosphorylation (yellow) of STAT3/6. STAT3/6 translocates into the nucleus where it promotes the expression of BATF-3, which dimerizes with c-JUN or JUNB to form stable and active AP-1 TFs. BATF-3/c-JUN dimers directly bind to the MYC gene promoter resulting in an increase in MYC and BATF-3 target gene expression, promoting proliferation and survival in CHL and ALCL. Figure adapted from [88].