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. 2018 Mar 28;10(4):94. doi: 10.3390/cancers10040094

Figure 1.

Figure 1

Overview of the Hippo signaling pathway in Drosophila (A) and mammals (B). Hippo signaling is initiated by a variety of upstream stimuli. Activation of Hippo (MST1/2) leads to subsequent phosphorylation of Warts (LATS1/2). Warts negatively regulates the Hippo pathway effector Yorkie (YAP/TAZ). Unphosphorylated Yorkie translocates into the nucleus where it interacts with its Scalloped (TEAD) transcription factors to upregulate the transcription of a variety of genes. In contrast, phosphorylation of Yorkie by Wts lead to its cytoplasmic sequestration by 14-3-3 proteins and degradation.