Table 3.
Malignant peritoneal mesothelioma (MPM) versus papillary serous peritoneal carcinomas (PSPCs) and non-gynaecological adenocarcinomas (ADCs) [31,32].
| Mesothelial Markers | |
| Calretinin | Useful. Positive in 85–100% of MPMs. Positivity in 0–38% of PSPCs prevents its use as a single differential marker. |
| D2-40 | Potentially useful. Positive in 93–96% of MPMs but also focal positivity in 13–65% of PSPCs; additional data are needed. |
| CK5/6 | Limited use. Positive in 53–100% of MPMs but also focal positivity in 22–35% of PSPCs. |
| WT1 | Not useful. Positive in 43–93% of MPMs and positive in 89–93% of PSPCs. |
| PSPCs Markers | |
| MOC-31 | Very useful. Positive in 98% of PSPCs and 5% of MPMs. |
| PAX8 | Very useful. Positive in most Mullerian carcinomas and negative in MPMs. |
| BG8 | Very useful. Positive in 73% of PSPCs and 3–9% of MPMs. |
| BerEP4 | Useful. Positive in 83–100% of PSPCs and in 9–13% of MPMs. |
| B72.3 | Limited use. Positive in 65–100% of PSPCs and focal expression in 0–3% of MPMs. |
| CEA | Not useful. Positive in only 0–45% of PSPCs and negative in MPMs but sensitivity too low compared to other markers. |
| Oestrogen receptor | Useful. Positive in 60–93% of PSPCs and 0–8% of MPMs. |
| Progesterone receptor | Limited use. Lower sensitivity than oestrogen receptors in PSPCs, negative in MPMs. Can be useful when positive. |
| Mesothelioma vs. Non-Gynaecological Adenocarcinoma (Biliary, Pancreas, Stomach, Colon) | |
| Calretinin | Very useful. Positive in 85–100% of MPMs but also positive in 10% of pancreatic ADCs, limited value as single marker. |
| WT1 | Very useful. Positive in 43–93% of MPMs, 3% of gastric ADCs and 0% of pancreatic ADCs. |
| D2-40 | Potentially useful. Positive in 93–96% of MPMs, negative in gastric and pancreatic ADCs (limited data). |
| CK5/6 | Not useful. Positive in 53–100% of MPMs and 38% of pancreatic ADCs. |
| MOC-31 | Very useful. Positive in 5% of MPMs and 87% of ADCs. |
| BG8 | Very useful. Positive in 3–9% of MPMs and 89% of ADCs. |
| CEA | Very useful. Negative in MPMs and positive in 81% of ADCs. |
| B72.3 | Very useful. Positive in 0–3% of MPMs, 84% of pancreatic ADCs, 89% of biliary ADCs, 98% colon ADCs. |
| BerEP4 | Useful. Positive in 9–13% of MPMs et >98% pancreatic and gastric ADCs. |
| CDX2 | Useful. Positive in 90–100% of colon ADCs, 80% small intestine ADCs, 70% of gastric ADCs and negative in MPMs. |