Table 4.

IHC tumour staining patterns in the differential diagnosis of CUPs expressing CK7+/CK20+ [1,7].

Primary Origin Site	Immunostaining Profile
Lung (mucinous) [49]	TTF1−/+, CK7−/+, CDX2−/+
Pancreas [26,27,50,51]	Maspin A+, S100P+, IMP-3+, pVHL−, SMAD4−/+, MUC5AC+, CDX2−/+
Stomach [26,27,50,51]	CEA+, CDX2−/+, MUC1−/+, MUC5AC−/+, CDH17+/−, TTF1−
Oesophagus [26,27,50,51]	CEA+, MUC5AC+/−, CDH17+, MUC1−/+, CDX2−/+
Ovary (mucinous) [7,52]	DPC4+, CA-12.5+, CDX2+/−
Urinary bladder [17,18,19,20,21]	GATA3+, p63+, p40+, CK5/6+, CK20+/−, S100P+, CK903+, UPIII+/−
Small intestine [39]	CDX2+, CDH17+, Villin+/−, MUC5AC+/−
NUT midline carcinoma [53,54,55]	CK7+/−, CK20+/−, p40+/−, NUT