Table 5.

IHC tumour staining patterns in the differential diagnosis of CUPs expressing CK7−/CK20− [1,7].

Primary Site	IHC Profile
Prostate [58,59,60,61,62]	PSA+, NKX3.1+/−, PSAP+, P504S+, ERG+/−
Colon (medullary) [29,35,36]	SATB2+, CDH17+, TFF3+/−, Calretinin+/−, CDX2−/+
Renal [21,63]	CD10+, PAX8+, Vimentin+, pVHL+, RCCMa+, Inhibin−, TTF1−, CEA−
Liver [64]	HepPar1+, CD10+, pCEA+, mCEA−, AFP+, Glypican-3+, Arginase-1+, CK19−
Adrenal (cortical) [4,7,10]	Melan A+, Calretinin+, Inhibin A+, Synaptophysin+, Chromograni−, CEA−
Germ cell tumours [4,7,10]	CD117+, OCT4+, CD30+, Glypican-3+, PLAP+, SALL4+, NANOG+