Table 2.
Cytotoxic activities of compounds 1–5 against human tumor cell lines.
| Compound | IC50 (µM) | |||||
|---|---|---|---|---|---|---|
| HL-60 | MM231 | A-549 | HEP3B | SW480 | NCM460 | |
| 1 | >40 | >40 | >40 | >40 | >40 | >40 |
| 2 | 4.92 ± 0.65 | >40 | 8.60 ± 1.36 | 5.50 ± 0.67 | 21.17 ± 2.72 | >40 |
| 3 | 25.63 ± 3.84 | >40 | >40 | >40 | >40 | >40 |
| 4 | >40 | >40 | >40 | >40 | >40 | >40 |
| 5 | 21.77 ± 3.48 | >40 | 18.41 ± 2.15 | >40 | >40 | >40 |
| Cis-platin 1 | 1.63 ± 0.11 | 3.84 ± 0.25 | 2.79 ± 0.36 | 2.96 ± 0.22 | 1.42 ± 0.11 | 0.85 ± 0.07 |
| Paclitaxel 1 | <0.008 | <0.008 | <0.008 | <0.008 | <0.008 | <0.008 |
1 Cis-platin and paclitaxel were used as positive controls.