Table 2.
Pharmacokinetic parameters of fucoidan in plasma and tissues after intragastric administration to rats.
| Sample | Parameters | |||
|---|---|---|---|---|
| AUC0–t (µg·h/g) * | MRT (h) | T1/2 (h) | ft | |
| Plasma | 0.99 ± 0.27 | 6.79 ± 1.63 | 3.44 ± 1.70 | - |
| Liver | 3.26 ± 1.54 | 9.25 ± 3.78 | 6.44 ± 3.57 | 3.29 |
| Kidneys | 10.74 ± 5.15 | 12.39 ± 4.26 | 7.26 ± 3.09 | 10.85 |
| Spleen | 6.89 ± 2.87 | 14.57 ± 6.51 | 9.32 ± 5.12 | 6.96 |
| Striated muscle | 1.49 ± 0.22 | 5.43 ± 0.82 | 2.36 ± 0.84 | 1.50 |
| Omentum | 1.10 ± 0.22 | 7.78 ± 0.93 | 4.30 ± 0.79 | 1.11 |
* AUC0–t (μg·h/mL) for plasma. AUC0–t, the area under the curve; MRT, mean residence time; T1/2, apparent half-life of elimination; ft, the tissue availability. The results are expressed as the mean ± SD (n = 5).