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Biological activity of BFA and its ester analogs.
| Compound | MGM 1 of GI50 (µM) | Compound | MGM of GI50 (µM) |
|---|---|---|---|
| 1 BFA | 0.04 ± 0.019 | 45 | 0.47 ± 0.001 |
| 42 | 13.00 | 46 | 5.10 |
| 43 | 97.72 | 50 | 29.51 |
| 44 | 0.11 ± 0.003 | 51 | 0.16 ± 0.002 |
1 MGM: mean graph midpoint values of A-549 (lung), HCT-116 (colon), SF-539 (CNS), UACC-62 (melanoma), OVCAR-3 (ovarian), SN12C (renal), PC3 (prostate), and MCF7 (breast) cell lines.
