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. 2018 Apr 27;8:6652. doi: 10.1038/s41598-018-24866-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Complete inhibition of bone resorption associated with the LPS model of experimental periodontal disease by local administration of nanocurcumin. Palatal view of representative images of three dimensional reconstructions of the hemi-maxillae in each experimental condition. The bar graph presents the quantitative results of the ratio of mineralized tissue (BV/TV) in the defined standardized ROI, according to the experimental condition. Data from 8 hemi-maxillae of each experimental condition analyzed by ANOVA followed by Tukey post-hoc test (*p < 0.05, ‘ns’ indicates lack of significance in comparison to PBS/vehicle injected hemi-maxillae.